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KMID : 1009020190170040495
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Clinical Psychopharmacology and Neuroscience
2019 Volume.17 No. 4 p.495 ~ p.502
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The Potential Utility of Aripiprazole Augmentation for Major Depressive Disorder with Mixed Features Specifier: A Retrospective Study
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Han Chang-Su
Wang Sheng-Min
Bahk Won-Myong
Lee Soo-Jung
Patkar Ashwin A.
Masand Prakash S.
Pae Chi-Un
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Abstract
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Objective: The present study aimed to observe potential benefit of aripiprazole augmentation in the treatment of major depressive disorder with mixed specifier (MDDM) in naturalistic treatment setting.
Methods: Data were collected from MDDM patients using a retrospective chart review for 8 weeks (week ?8 and week 0) in routine practice. All patients were on current antidepressants upon starting of aripiprazole. Patients were treated without restriction of doses of aripiprazole. The primary endpoint was the mean change of Montgomery?Asberg Depression Rating Scale (MADRS) total scores along with various secondary endpoint measures.
Results: In total 38 patients were analyzed. The changes of MADRS, Clinical Global Impression (CGI)-severity, Young Mania Rating Scale, Sheehan Disability Scale, and CGI-clinical benefit total scores from baseline to the endpoint were ?7.1, ?0.8, ?4.9, ?4.1, and ?3.6, respectively (all p < 0.0001). At the endpoint, the responder and remitter rates by MADRS score criteria were approximately 32% and 21%, respectively.
Conclusion: The present findings have clearly shown the effectiveness and tolerability of aripiprazole augmentation for MDDM patients in routine practice. The present study warrants subsequent, adequately-powered, well-controlled studies for generalizability near future.
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KEYWORD
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Aripiprazole, Depressive disorder, Mixed specifier, Effectiveness, Tolerability
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